Endocrine Abstracts

Background: CCH and serum hypercalcitoninemia (iperCT) can be found in benign thyroid diseases such as thyroiditis and in some cases of papillary (PTC) or follicular (FTC) thyroid microcarcinomas. The question of whether the association with these latter is related to the malignancy of the nodule is still unclear.Aim of the study: To evaluate the difference in the CCH prevalence, at histology, in a series of benign (BTN) and malignant (PTC/FTC) thyroid n...

The distinct roles of estrogen receptors (ERs) related with androgen receptors (ARs) have been proposed in prostate cancer, while the involvement of transforming growth factor-β (TGF-β) has been reported in prostate cancer progression. We examined that TGF-β signaling pathway is associated with ER signaling in LNCaP prostate cancer cells, which express ERα and ERβ, and ARs. We determined whether the exposure to phthalate may induce the prostate cancer ...

Our aim was to evaluate the impact of some clinical (obesity, metabolic syndrome), biochemical (HOMA-IR), histological (fibrosis, necroinflammation, steatosis) and viral factors (HCV viraemia) on both EVR and SVR in patients with genotype 1 chronic hepatitis C (CHC) treated with peginterferon plus ribavirin.Patients and methods: We evaluated retrospectively 188 naïve patients with CHC treated with peginterferon plus ribavirin at standard weight-base...

Arginine and other aminoacids have been reported to induce GH discharge, even if their site of action has not been clearly established. The aim of this study was to determine the effects of different culture media on GH secretion by pig pituitary cells. Pituitary cells from adult female pigs were cultured for 72 h in the following media: DMEM-F12 (Group A), DMEM-F12 SALTS (Group B) and DMEM-F12 ARGININE FREE (Group C), in standard culture condition (0-48 h: FCS 10%; 48-72 h: F...

A 52 year old lady with hypothyroidism and hypertension was referred by her GP for unexplained low blood glucose on several occasions. There was history of vacant spells with confusion and disorientation over the previous year. When referred for neurological assessment, no abnormality was identified. Her medications included amlodipine 5 mg, ramipril 10 mg, thyroxine 50 mcg, loratidine 10 mg. Her BMI was 44 kg/m2.Additional investigations arra...

IntroductionMaturity Onset Diabetes of the Young (MODY) type 1 is characterized by mutations in hepatocyte nuclear factor 4a (HNF4a) gene, leading to progressive dysfunction of pancreatic beta-cells with optimal response to sulphonylurea treatment. However, most of these patients are initially misdiagnosed as having type 1 diabetes and inappropriately treated with insulin. Data on adequate transferring from insulin to sulphonylureas following gen...

Abundant evidence demonstrates that long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous study shows a significant association between IL4 genotypes and T2DM, as well as between IL4 genotypes and the lower circulatory levels of high-density lipoprotein-cholesterol (HDL-C). In addition, IL4 has anti-hyperglycemic function by improving insulin sensitivity and glucose tolerance as well as being involved in lipid m...

Context: Polycystic ovary syndrome (PCOS) and gestational diabetes (GDM) are two common metabolic disorders. The serum oxidative stress markers advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) have been found to be elevated in women with PCOS and GDM compared to controls. However the impact of these harmful molecules to their offspring is under investigation.Objective: To evaluate AGEs and AOPPs serum levels along wi...

Both of peroxisome proliferator-activated receptor gamma (PPARγ) and estrogen receptor (ER) contribute to the development of thyroid cancer. Previously, the activation of ERα was found to promote the proliferation of thyroid cancer cells, whereas activation of either ERβ or PPARγ resulted in apoptosis of thyroid cancer cells. Furthermore, a transactivation between ER and PPARγ was reported in estrogen-responsive malignancy, such as breast cancer. Howev...

Dyslipidemiαs should be managed from childhood for prevention of early atheromatic vascular lesions and premature cardiovascular disease in adult life.Aim: We examined the frequency of different types of dyslipidemiα in children and the results on blood lipids of lifestyle intervention (diet and exercise).Patients and methods: We studied retrospectively 136 children, 74 boys and 62 girls, mean chronological age 8.5±3...